Challenges of Haematopoietic Stem Cell Transplantation in Primary Immunodeficiency Disorders in a Developing Country

stem cell transplantation for treatment of primary immunodeficiency disorders

primary immunodeficiencies constitute a group of highly complex congenital disorders most of which are characterized by a very poor prognosis. allogeneic hematopoietic stem cell transplantation (hsct) has become an established curative treatment approach in many of these disorders, which may be permanently corrected. in this presentation basic and practical aspects of hsct are presented, with a...

Stem cell transplantation for treatment of primary immunodeficiency disorders.

Primary Immunodeficiencies constitute a group of highly complex congenital disorders most of which are characterized by a very poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT) has become an established curative treatment approach in many of these disorders, which may be permanently corrected. In this presentation basic and practical aspects of HSCT are presented, with a...

Developments in haematopoietic stem cell transplantation.

Haematopoietic stem cell transplantation remains the treatment of choice for a variety of benign and malignant blood disorders.1 In this modality Haematopoietic stem cell transplantation is the intravenous infusion of haematopoietic stem and progenitor cells to re-establish marrow function in patients with damaged or defective marrow. The procedure is called Bone Marrow Transplantation (BMT) if...

In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)

In utero haematopoietic stem cell transplantation (IUHSCT) is a non-myeloablative approach for the prenatal treatment of genetic disorders. However, in target disorders, where there is not a selective advantage for donor cells, a useful donor-cell chimerism has not been achieved. There are three possible barriers to engraftment following IUHSCT: limited space in the fetus due to host-cell compe...

Stem Cell Transplantation for Primary Immunodeficiency